ArticleAnnals of neurosciences2025
Optimising Paediatric Brain Mapping with Single-Pulse Transcranial Magnetic Stimulation: A New Protocol and Insights.
Article in Annals of neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Single-pulse paradigms of transcranial magnetic stimulation (TMS) have been used to understand cortical excitability and reorganisation. Purpose: This study aims to develop a protocol for mapping of the primary motor cortex (M1) using single-pulse TMS in children. Methods: A 11×11 manual grid was created around the hotspot of abductor pollicis brevis (APB). Motor-evoked potential (MEP) amplitude was recorded from 41 sites around the hotspot of APB and analysed. Results: Maximum MEP amplitude was recorded from the hotspot that reduced as distance increased. Heat maps generated were consistent among the participants. Conclusion: In children, 41 single-pulse TMS stimulations with interstimulus interval of two seconds provide reliable information about motor maps. This procedure will aid in understanding cortical reorganisation in children with neurodevelopmental disorders.
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