ArticleFrontiers in veterinary science2025
Immunotherapeutic efficacy of recombinant canine IL-15 as an adjunct to chemotherapy in canine lymphoma.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Introduction: Canine lymphoma is a common hematopoietic malignancy with variable response to standard chemotherapy. Interleukin-15 (IL-15) is known to enhance cytotoxic lymphocyte activity, and this study aimed to evaluate the efficacy and safety of a recombinant canine IL-15 (rcIL-15) as an adjunct to chemotherapy in dogs with lymphoma. Methods: A total of 61 dogs diagnosed with lymphoma were enrolled in a 12-week clinical study. The test group received rcIL-15 in combination with standard chemotherapy, while the control group received chemotherapy alone. Outcome measures included tumor response rates, tumor biomarker levels (TK-1, LDH, β2-microglobulin), quality of life (QOL) assessments, and adverse event monitoring. Results: Of the 61 dogs enrolled, 37 completed the study. The test group demonstrated a higher overall response rate (complete + partial response: 77.8%) compared to the control group (57.9%). Disease progression was observed in 16.7% of dogs in the test group versus 31.6% in controls. Tumor biomarkers were significantly reduced in the test group: TK-1 at 8 weeks ( Discussion: Adjunctive rcIL-15 therapy improved tumor response, reduced biomarker levels, and enhanced QOL with an acceptable safety profile. These findings support the potential of rcIL-15 as a safe and effective immunotherapeutic adjunct for canine lymphoma, meriting further investigation in larger-scale trials.
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