ArticleFrontiers in microbiology2025
The short cytoplasmic region of phage T4 holin is essential for the transition from impermeable membrane protein complexes to permeable pores.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA-Enhanced Antibiofilm Activity.MicrobiologyOpen · 2026Article
- Bacteriophage Therapy AgainstAntibiotics (Basel, Switzerland) · 2026Review
- Identification and Characterization of Holin-like Protein ORF70 from Cyanophage MaMV-DC.Marine drugs · 2025Article
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6 authors.
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Abstract
Virulent as well as temperate phages usually require lysis of bacteria to release their progeny into the surrounding. Double-stranded DNA phages achieve lysis by phage-encoded endolysins that degrade the bacterial cell wall. Endolysins cross the cytoplasmic membrane by the aid of phage-encoded hole-forming membrane proteins, the holins. Canonical holins have been shown to multimerize and form very large holes in membranes, and it is believed that these holes enable a non-specific release of endolysins from cytoplasm. We studied these aspects with
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