Evidence map›Paper›PMID 40520367›Full record

ArticleMolecular therapy. Nucleic acids2025

Bile acid accumulation induced by miR-122 deficiency in liver parenchyma promotes cancer cell growth in hepatocellular carcinoma.

Jia-Hui Huang, Yi-Hang Li, Juan-Zhen Hong, Ruo-Nan Li, Ruizhi Wang, Zi-Qi Chen, Song-Yang Li, Ying-Lei Chi, Jin-Yu Huang, Ying Zhu

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-Hui HuangMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Yi-Hang LiMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Juan-Zhen HongMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Ruo-Nan LiMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Ruizhi WangDepartment of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, P.R. China.
Zi-Qi ChenMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Song-Yang LiMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Ying-Lei ChiMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Jin-Yu HuangMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.
Ying ZhuMOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver is the central player in maintaining metabolic homeostasis of bile acids (BAs), but how BA is tightly controlled is still largely unknown, and the role of BAs in the development of hepatocellular carcinoma (HCC) remains controversial. Here, we discovered that elevated hepatic BAs were associated with miR-122 downregulation during liver regeneration, steatosis, and fibrosis.

Indexed as

bile acidHCCHSD3B7miR-122MT: Non-coding RNAsparacancerous tissues

Identifiers

PMID40520367
PMCPMC12166698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.