ArticleJournal of trace elements and minerals2025
Comparison between inductively coupled plasma-mass spectrometry and benchtop X-ray fluorescence performance for trace elemental exposure in rat tissues.
Article in Journal of trace elements and minerals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Beginner's Guide for Using Bone in Marine Mammal Research.Integrative and comparative biology · 2026Guideline
- Rapid acquisition of ionomic and morphological data from plant seeds through fast X-ray fluorescence microscopy and computer vision.Plant phenomics (Washington, D.C.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Background: Trace elemental toxicants induce health detriment in almost every organ system in the human body and account for a large amount of environmental and ecological environmental pollution. Traditionally, inductively coupled plasma mass spectrometry (ICP-MS) has been the gold standard for measuring elemental concentrations in biological tissues collected from toxicological and epidemiological studies. However, ICP-MS is often limited by its complexity, cost, and time-intensive nature. Methods: This study investigates the feasibility of benchtop X-ray fluorescence (XRF) as an efficient alternative for trace elemental analysis in rat tissues, offering comparable quantification capabilities with enhanced operational simplicity. We conducted a comparative analysis using tissue samples from multiple rat organs, including stomach, eyes, and liver. Results: The elemental concentrations of Arsenic (As), Cadmium (Cd), Copper (Cu), Manganese (Mn), and Zinc (Zn) were measured using both ICP-MS and a high-powered benchtop XRF (Epsilon 4, Malvern Panalytical). Our findings demonstrated strong linear regression correlations between the two methods: As (R Conclusion: These results suggest that both ICP-MS and benchtop XRF are viable for elemental quantification in organ tissues, with benchtop XRF being more practical for low-mass samples. This study shows benchtop XRF's potential for high-throughput, accurate trace element analysis in biological samples, broadening its use in environmental and toxicological research. Synopsis: Human and ecological tissues of varying compositions and densities can be measured effectively using benchtop X-ray fluorescence.
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Registered trials
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