Evidence map›Paper›PMID 40520162›Full record

ArticleFrontiers in pharmacology2025

Respiratory virus-induced bacterial dysregulation in pediatric airway tissue and the dual actions of Echinacea in reducing complications.

Selvarani Vimalanathan, Mahfuza Sreya, Ranganayaki Nandanavanam, Roland Schoop, Giuseppe Gancitano, Saba Saberi, Anna Malikovskaia, James Hudson

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Selvarani VimalanathanPathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Mahfuza SreyaWomen+ and Children's Health Sciences, University of British Columbia, Vancouver, BC, Canada.
Ranganayaki NandanavanamApplied Biology, University of British Columbia, Vancouver, BC, Canada.
Roland SchoopMedical Department, A.Vogel AG, Roggwil, Switzerland.
Giuseppe GancitanoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Saba SaberiPathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Anna MalikovskaiaPathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
James HudsonPathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Respiratory tract infections (RTIs) contribute to pediatric morbidity and are often complicated by viral-bacterial superinfections, which exacerbate disease severity and increase antibiotic use. This study examined viral-induced bacterial adhesion in an Methods: EpiAirway tissue from a 6-year-old boy was infected with respiratory syncytial virus (RSV), human parainfluenza virus type 3 (HPIV3), or rhinovirus 14 (RV14). Adhesion of Results: RSV and HPIV3 increased bacterial adhesion by upregulating PAFr, ICAM-1, and CEACAM-1. Hib adhered primarily via ICAM-1, while Conclusion: Our findings provide a mechanistic explanation for the observed effects of

Indexed as

Echinacea purpureaEpiAirway viral-bacterial superinfectionsHaemophilus influenzae type bhuman parainfluenza virus type 3pediatricsrespiratory syncytial virusrhinovirusStreptococcus pneumoniae

Identifiers

PMID40520162
PMCPMC12163319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.