Evidence map›Paper›PMID 40520160›Full record

ArticleFrontiers in pharmacology2025

Improvement on mitochondrial energy metabolism of

He Li, Letian Zhang, Xingtai Li, Haocheng He, Guoan Fu, Yi Zhun Zhu, Wei Hu, Lige Qiu, Liang Gong, Youming Zhang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. A HeterogeneousInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

He Li *School of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, China.
Letian Zhang *School of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, China.
Xingtai LiCollege of Life Science, Dalian Minzu University, Dalian, China.
Haocheng HeShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Guoan FuShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Yi Zhun ZhuSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, China.
Wei HuSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, China.
Lige QiuSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, China.
Liang GongShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Youming ZhangSchool of Pharmacy, Faculty of Medicine and Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethnopharmacological relevance: Aim of the study: We extracted CPP from Methods: Based on the mice chronic hypoxia model for imitating the energy deficiency state of the human body, which was administered with CPP by oral gavage daily for 10 days, mitochondrial permeability transition (MPT), lipid peroxidation product malondialdehyde (MDA) in brain, mitochondrial respiratory function, the levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) in liver cells were assayed. Adenylate energy charge (AEC), total adenylate pool (TAP), ATP/ADP, and ATP/AMP ratios were calculated. Results: CPP can inhibit the formation of MDA in mice brains, decrease oxygen consuming rate and respiratory control ratio (RCR) of liver mitochondria, increase levels of ATP, TAP and AEC in liver cells under chronic hypoxia condition. Conclusion: CPP can possess and improve mitochondrial energy metabolism and bioenergetic levels.

Indexed as

adenosine triphosphateanti-hypoxiaCodonopsis pilosula (Franch.) Nannf. polysaccharideenergy metabolismmitochondriamitochondrial respiratory function

Identifiers

PMID40520160
PMCPMC12162984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.