ArticleiScience2025
Spatiotemporal properties of cortical excitatory and inhibitory neuron activation by sustained and bursting electrical microstimulation.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Learning induces activation-mechanism-dependent neural plasticity in an intracortical microstimulation task.Science advances · 2026Article
- Microglia surveillance is directed toward neuron activation during sustained intracortical microstimulation.Journal of neural engineering · 2026Article
- Leveraging epileptic network understanding to improve targeted treatment.PLoS biology · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chronic alteration of CabioRxiv : the preprint server for biology · 2025Article
- Optimal interphase delay in biphasic current pulses facilitates neural circuit activation induced by microstimulation in the mouse visual cortex.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Intracortical microstimulation (ICMS) of sensory brain regions can create artificial sensations, yet these percepts fade with continued stimulation, suggesting dynamic changes in underlying neural activity. Using two-photon imaging in transgenic mice, this study examines how prolonged ICMS (30 s) shapes activity in excitatory and inhibitory neurons within the visual cortex. Inhibitory neuron activity was more likely to increase throughout the stimulation period, while excitatory neuron activity was more likely to decrease and be suppressed post-stimulation. Stimulation patterns differentially shaped neuronal engagement: theta-burst stimulation most effectively activated inhibitory neurons, whereas 10-Hz burst most effectively activated excitatory neurons. ICMS evoked more diverse responses in neurons farther from the electrode, reflecting complex synaptic interactions involving inhibition and disinhibition. These results show that ICMS affects excitatory and inhibitory neurons differently over extended durations. Modulation of stimulation patterns may allow for preferential engagement of specific neuron types and shaping of cortical activity.
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Registered trials
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