Evidence map›Paper›PMID 40520106›Full record

ArticleiScience2025

β-adrenergic signaling modulates breast cancer cell mechanical behaviors through a RhoA-ROCK-myosin II axis.

Tae-Hyung Kim, Minh-Tam Tran Le, Mijung Oh, Esteban Vazquez-Hidalgo, Bryanna Chavez, Donald M Lamkin, Alexander Abdou, Xing Haw Marvin Tan, Alexei Christodoulides, Carly M Farris and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tae-Hyung KimDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Minh-Tam Tran LeDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Mijung OhDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
Esteban Vazquez-HidalgoMechanical Engineering Department, San Diego State University, San Diego, CA, USA.
Bryanna ChavezDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Donald M LamkinCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Alexander AbdouDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Xing Haw Marvin TanDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Alexei ChristodoulidesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Carly M FarrisMechanical Engineering Department, San Diego State University, San Diego, CA, USA.
Changhoon LeeDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Pei-Yu ChiouDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Erica K SloanDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.
Parag KatiraMechanical Engineering Department, San Diego State University, San Diego, CA, USA.
Amy C RowatDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
TALENT Shared Resources CoreU54CA285115 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard Matthew Cripps, MARIA ELENA MARTINEZ · 2023 to 2026
$6.6M
Research Education CoreU54CA285117 · NCI · SAN DIEGO STATE UNIVERSITY · PI Richard Matthew Cripps, MARIA ELENA MARTINEZ · 2023 to 2026
$6.2M
NCI NIH HHS P30 CA016042NCI NIH HHS U54 CA285115NCI NIH HHS U54 CA285117
6 · The paper itself

Abstract

The ability of cancer cells to deform and generate force is implicated in metastasis. We previously showed that β-adrenergic agonists increase cancer cell stiffness, which was associated with enhanced motility and invasion. Here, we investigate how β-adrenoceptor (βAR) activation alters the mechanical behaviors of triple-negative breast cancer cells. We find that βAR activation increases traction forces in metastatic MDA-MB-231

Indexed as

Cell biologyFunctional aspects of cell biologyMechanobiology

Identifiers

PMID40520106
PMCPMC12164020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.