Evidence map›Paper›PMID 40520098›Full record

ArticleiScience2025

An intracellular release peptide display technology unveils an antimicrobial peptide with low probability for resistance development.

Anna Ebbensgaard, Catrina Olivera, Thomas Bentin, Henrik Franzyk, Godefroid Charbon, Peter E Nielsen, Anders Løbner-Olesen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna EbbensgaardDepartment of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Catrina OliveraDepartment of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Thomas BentinThe Novo Nordisk Foundation, Tuborg Havnevej 19, 2900 Hellerup, Denmark.
Henrik FranzykDepartment of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.
Godefroid CharbonDepartment of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Peter E NielsenCenter for Peptide-based Antibiotics, Department of Cellular and Molecular Medicine, The Panum Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.
Anders Løbner-OlesenDepartment of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Discovery of bioactive peptides, including those acting to permeabilize and/or kill bacterial cells (antimicrobial peptides) has drawn extensive interest in recent years. However, current technologies for their identification are limited. To address these limitations, the Intracellular Release Peptide Display (IRPD) technology allowing the recombinant "display" of intracellular linear peptides was developed. IRPD uses the protease domain of the capsid protein from the Semliki Forest virus as a scaffold to express and liberate linear peptides intracellularly in

Indexed as

Applied microbiologyMicrobiologyPeptides

Identifiers

PMID40520098
PMCPMC12164208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.