Evidence map›Paper›PMID 40520088›Full record

ArticleiScience2025

Anti-OX40 antibody BAT6026 in patients with advanced solid tumors: A multi-center phase I study.

Huaqiang Zhou, Yuxiang Ma, Yongsheng Li, Long Tang, Yubiao Guo, Gang Yuan, Ziyi Fu, Jin-Chen Yu, Li Zhang, Hongyun Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Novel Therapeutic Development for Nasopharyngeal Carcinoma.Current oncology (Toronto, Ont.) · 2025
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huaqiang ZhouDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, China.
Yuxiang MaDepartment of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, China.
Yongsheng LiChongqing University, Cancer Hospital, Chongqing 400030, China.
Long TangChongqing University, Cancer Hospital, Chongqing 400030, China.
Yubiao GuoSun Yat-sen University, The First Affiliated Hospital, Guangzhou 510080, China.
Gang YuanSun Yat-sen University, The First Affiliated Hospital, Guangzhou 510080, China.
Ziyi FuBio-Thera Solutions, Ltd., Clinical Development Department, Guangzhou 510000, China.
Jin-Chen YuBio-Thera Solutions, Ltd., Clinical Development Department, Guangzhou 510000, China.
Li ZhangDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, China.
Hongyun ZhaoDepartment of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BAT6026 is a fully human IgG1 OX40 monoclonal antibody. This was a multicenter, open-label, dose escalation, and dose expansion phase I study of BAT6026 conducted in patients with advanced solid tumors who failed standard treatment. Patients received BAT6026 injections ranging from 0.01-10 mg/kg on day 1 of every 3 weeks (Q3W) in dose escalation. In dose expansion phase, 6 patients received 10 mg/kg BAT6026 (Q3W). Thirty patients were enrolled, with 24 in the dose escalation phase and 6 in the dose expansion phase. BAT6026 was generally well tolerated and demonstrated an adequate safety profile at doses ranging from 0.01 mg/kg and 10 mg/kg. In 26 patients who were efficacy evaluable, 10 of them achieved stable disease and the disease control rate (DCR) is 38.5%. Further studies including combined with other immunotherapies and some new drug delivery modality and regimen need to be investigated.

Indexed as

Health sciencesInternal medicineMedical specialtyMedicineOncology

Identifiers

PMID40520088
PMCPMC12164209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.