Evidence map›Paper›PMID 40520053›Full record

ArticleFrontiers in systems neuroscience2025

Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas.

Sunil Dhungel, Shavana R L Rana, Arun Kumar Neopane, Barun Mahat, Bipin Kumar Shrestha, Yesha Shree Rajaure, Bikalp Thapa, Naveen Phuyal, Naresh Manandhar, Udaya Shrestha and 2 more

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Article in Frontiers in systems neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Sunil DhungelDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Shavana R L RanaDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Arun Kumar NeopaneDepartment of Pediatrics, Shree Birendra Hospital, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Barun MahatDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Bipin Kumar ShresthaDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Yesha Shree RajaureDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Bikalp ThapaDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Naveen PhuyalDepartment of Community Medicine, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Naresh ManandharDepartment of Community Medicine, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Udaya ShresthaShree Birendra Military Hospital (SBH), Kathmandu, Nepal.
Suraj ParajuliDepartment of Clinical Skills, Medical University of the Americas, Charlestown, Saint Kitts and Nevis.
Taraman AmatyaDepartment of Clinical Physiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: High-altitude environments challenge cognitive function due to hypoxia, yet their specific effects on cerebral lobe functions remain unclear. This study examines the impact of high-altitude exposure on frontal, parietal, temporal, and occipital lobes in climbers in the Nepali Himalayas, aiming to enhance understanding of altitude-related cognitive decline. Methods: A cross-sectional cohort study was conducted with 76 participants, including 46 non-selected individuals (NOSCL) and 30 selected climbers divided into Everest (EMCL, Results: Significant altitude-related declines were observed in frontal lobe function, particularly in the Visual Stroop test at 800 meters (75%, Discussion: The findings indicate that frontal lobe functions are particularly vulnerable to hypoxia at high altitudes. The results support the necessity of region-specific cognitive testing for high-altitude risk assessments. Further research should explore long-term cognitive effects and mitigation strategies for climbers exposed to extreme altitude conditions.

Indexed as

acclimatationcerebral lobe functionhigh-altitudehypoxiaNepal

Identifiers

PMID40520053
PMCPMC12162956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.