Evidence map›Paper›PMID 40519982›Full record

ArticlePhotoacoustics2025

Photoacoustic imaging detects cerebrovascular pathological changes in sepsis.

Zhigang Wang, Changpeng Ai, Ting Sun, Zhiyang Wang, Wuyu Zhang, Feifan Zhou, Shengnan Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhigang WangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China.
Changpeng AiKey Laboratory of Brain Health Intelligent Evaluation and Intervention, Ministry of Education, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Ting SunKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya 572024, China.
Zhiyang WangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China.
Wuyu ZhangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China.
Feifan ZhouKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya 572024, China.
Shengnan WuKey Laboratory of Brain Health Intelligent Evaluation and Intervention, Ministry of Education, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, involving acute brain dysfunction. Although cerebrovascular impairment plays a critical role in SAE, sepsis-induced microvascular changes remain poorly quantified. Here, we used photoacoustic microscopy to dynamically assess blood-brain barrier permeability in septic mice, analyzing vascular structure across five parameters. Additionally, we examined pathological changes in major cortical regions and conducted behavioral tests to validate the findings. Results showed microvascular degeneration, including reduced vascular density and branching, alongside an increase in fine vessels. Motor-related cortical areas were most affected, correlating with severe motor and cognitive deficits in septic mice. This study provides the first

Indexed as

Blood-brain barrier permeabilityCerebrovascular morphologyCortical brain regionsPhotoacoustic microscopySepsis-associated encephalopathy

Identifiers

PMID40519982
PMCPMC12166994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.