Evidence map›Paper›PMID 40519940›Full record

ArticleBiofilm2025

Proteomic signatures of

C Kuik, C de Boer, S W G van Hoogstraten, K Freulings, M Honing, J J C Arts, B Cillero-Pastor

Abstract read
In one paragraph

Article in Biofilm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Biofilm formation associated with calcium phosphate coating on implant metals.Journal of materials science. Materials in medicine · 2026
    Article
  5. Review
  6. Surface Oxide Film and Antibacterial Activity of Zirconium-Based Bulk Metallic Glasses.Langmuir : the ACS journal of surfaces and colloids · 2026
    Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C KuikMaastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
C de BoerDepartment of Orthopaedic Surgery, Laboratory for Experimental Orthopaedics, CAPHRI, Maastricht University Medical Center, Maastricht, the Netherlands.
S W G van HoogstratenDepartment of Orthopaedic Surgery, Laboratory for Experimental Orthopaedics, CAPHRI, Maastricht University Medical Center, Maastricht, the Netherlands.
K FreulingsMaastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
M HoningMaastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
J J C ArtsDepartment of Orthopaedic Surgery, Laboratory for Experimental Orthopaedics, CAPHRI, Maastricht University Medical Center, Maastricht, the Netherlands.
B Cillero-PastorMaastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections pose a significant clinical challenge in the orthopaedic field, often leading to implant failure and revision surgeries. These infections are hard to treat, particularly due to the formation of bacterial biofilms. Orthopaedic implant surfaces feature varying roughness and compositions to optimise implant osseointegration and performance. Highly polished surfaces are used in articulating areas of high shear force to minimise wear particle formation, while rough or porous surfaces enhance implant and bone fixation. However, increased surface roughness or porosity can also promote bacterial adhesion and biofilm formation, potentially elevating the risk of chronic infections. In this study, an automated single-pot solid-phase enhanced sample preparation protocol (SP3) workflow was developed to investigate the differences in proteomic response of immature and mature

Indexed as

AMRBacterial infectionBiofilmOrthopaedic implantsProteomics

Identifiers

PMID40519940
PMCPMC12167111

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.