Evidence map›Paper›PMID 40519926›Full record

ArticleFrontiers in immunology2025

Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration.

Idan Farber, Muhammad Wated, Ronen Schuster, Lihie Sheffer, Yuval Anav, Navit Ogen-Shtern, Alexandra Tsitrina, Diya Tacruri, Anna Bunin, Noah Benjamin Nagar and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Idan Farber *Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Muhammad Wated *Department of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.
Ronen SchusterDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Lihie ShefferDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Yuval AnavDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Navit Ogen-ShternThe Skin Research Institute, The Dead-Sea and Arava Science Center, Masada, Israel.
Alexandra TsitrinaMicroscopy and Flow Cytometry Unit, Ilse Katz Institute of Nanoscale Science, Beer-Sheva, Israel.
Diya TacruriDepartment of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.
Anna BuninDepartment of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.
Noah Benjamin NagarDepartment of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.
Maayan Hagbi BalDepartment of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.
Tomer EliyahuDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Dor HalpernDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Boris KnyazerDepartment of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.
Samuel CohenDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Sabri El-SaiedDepartment of Otolaryngology-Head and Neck Surgery, Soroka University Medical Center, Beer-Sheva, Israel.
Eli C LewisDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Eldad SilbersteinDepartment of Plastic and Reconstructive Surgery, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Erez TsumiDepartment of Ophthalmology, Soroka University Medical Center, Beer-Sheva, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Regulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation and promoting re-epithelialization across various epithelial cell types. Methods: Results: Conclusions: hAAT enhances re-epithelialization by modulating inflammation, promoting epithelial cell migration, and regulating expression of adhesion molecules.

Indexed as

alpha 1-AntitrypsinCell MovementInflammationRe-EpithelializationA549 CellsAnimalsCell Adhesion MoleculesCell LineEpithelial CellsHumansMiceMice, Inbred C57BLWound Healingalpha 1-AntitrypsinCell Adhesion Moleculesadhesion moleculescorneal abrasiondesmosomesgene expressionhemidesmosomesinflammationwound Healing

Identifiers

PMID40519926
PMCPMC12162329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.