ReviewFrontiers in immunology2025
Control of MAIT cell functions by cytokines in health and disease.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Mucosal-associated invariant T cells and the gut-kidney axis: a review.Clinical kidney journal · 2026Review
- The Role of Innate T Cells in Inflammatory Disorders in Asthma and Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that express a semi-invariant T cell receptor (TCR). These cells predominantly reside in tissues, such as the liver, lung, skin and the gastrointestinal tract. MAIT cells can be activated via their TCR that recognizes riboflavin metabolites presented by the MHC class I-related protein 1 (MR1). These cells can also be activated in a TCR-independent manner by cytokines, in particular IL-12 and IL-18, but also by type I interferons, IL-7, IL-15 and IL-23, underlining their innate-like characteristics. MAIT cells have important functions in antibacterial and viral immunity but also in tissue repair and homeostasis. Recent studies highlighted the plasticity of MAIT cells in response to cytokines, suggesting an important role of the cytokine milieu in modulating MAIT cell functions. Here, we discuss how cytokines control MAIT cell functions in various contexts.
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Registered trials
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