ArticleFrontiers in immunology2025
Associations between total protein, globulin, and nasal Methicillin-Resistant
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: There is limited evidence on the association between total serum protein (TP), serum globulin (GLB), and Methicillin-Resistant Methods: Using NHANES 2001-2004 data, we employed propensity score matching (PSM) to control confounders, weighted logistic regression to evaluate associations of TP and GLB with MRSA colonization, restricted cubic splines (RCS) for non-linear analysis, and subgroup and sensitivity analyses for validation. Results: Among 7,585 adults, 1.31% (n = 99) had MRSA nasal colonization. Adjusted multivariable regression identified TP and GLB as independent protective factors (TP: OR=0.92, 95%CI 0.88-0.96; GLB: OR=0.91, 95%CI 0.86-0.97; p< 0.05 for all). Categorizing TP and GLB into quartiles (Q4 vs. Q1) reinforced this association (TP: OR=0.21, 95%CI 0.07-0.59; GLB: OR=0.28, 95%CI 0.12-0.67; p< 0.05 for all) with consistent results post-PSM. Restricted cubic splines confirmed dose-dependent negative correlations. Subgroup analyses and sensitivity analyses supported the robustness of these findings. Conclusion: There was a negative correlation between TP, GLB, and MRSA nasal colonization in participants aged 18 years or older. Our data support the protective role of TP and GLB in MRSA colonization, and the specific mechanisms of these biomarkers in MRSA colonization and their clinical implications require further investigation.
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