ArticleInfection and drug resistance2025
The Effectiveness of Antiretroviral Therapy in Mitigating New HIV Infections in Southwest China: An Ecological Study.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Delineating the "who-where-how" of persistent HIV epidemics: a 23-year longitudinal genetic network, phylodynamic, and spatial analysis for precise intervention in rural China.Emerging microbes & infections · 2026Article
- Illness Perception Clusters Moderated the Association Between HIV-related Stigma and Resilience in Mother-Child Dyads Living with HIV: An Actor-Partner Interdependence Moderation Approach.AIDS and behavior · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antiretroviral therapy (ART) has been shown to reduce the number of local HIV (Human Immunodeficiency Virus) reported cases; however, there is insufficient research on the relationship between new HIV infections and ART. This study utilized real-world data to evaluate the community-level effectiveness of ART in reducing new HIV infections. Methods: Ecological study was designed to establish the relationship between ART quality and new HIV infections. New HIV infections were identified through an expanded testing system in 2018-2023; ART quality was evaluated based on ART-treated clients in 2016-2023, and non-probabilistic sampling was performed. Generalized linear models was employed to assess associations between metrics of ART effectiveness and new HIV infections. Statistical significance was set at Results: A total of 3836 new HIV infections were identified, yielding an overall incidence of 2.1%. Treatment coverage for the entire population was 80.8%, and the proportion of clients with an increased CD4 count was 61.0% of the entire population. In the generalized linear modeling, four key factors were associated with reduced new HIV infections: a greater number of clients undergoing treatment, a higher proportion of clients demonstrated CD4 count improvement, higher level of CD4 in baseline, and a reduction in reported cases ( Conclusion: This ecological study verified that expanding treatment coverage, optimizing the effectiveness of antiretroviral treatment and elevating baseline CD4 counts could curb community-level new HIV infections. Early detection, prompt treatment, and effective ART are crucial for curbing HIV transmission in regions mainly driven by sexual transmission and with high cumulative incidence rates.
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