Evidence map›Paper›PMID 40519868›Full record

ArticleJID innovations : skin science from molecules to population health2025

Weak Sensitizers May Be Associated with CD80 Polymorphisms: Implications for Systemic Contact Dermatitis.

Susan Nedorost, Ge Zhang, Desta Fekedulegn, Kara Fluharty, Wei Wang, Bonnie Frye, Elma Baron, Kathryn Zug, Berran Yucesoy

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In one paragraph

Article in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Epithelial-Dermal Immune Memory: TrackingInternational journal of molecular sciences · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susan NedorostDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Ge ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
Desta FekedulegnHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
Kara FluhartyHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
Wei WangNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Bonnie FryeHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
Elma BaronDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Kathryn ZugDepartment of Dermatology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire, USA.
Berran YucesoyHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic irritant dermatitis predisposes to Th2 skewed allergic contact dermatitis. Chronic hand dermatitis due to wet work or childhood- onset irritant flexural dermatitis (AD) is associated with sensitization to weak or non-sensitizing antigens as defined by the local lymph node (LLN) assay. In about 15% of these patients, ingestion of allergens results in systemic contact dermatitis, defined as recall dermatitis at previous sites. In this large exploratory study, not even known associations (e.g. IL4R and AD) survived correction for tests of multiple associations. As such, we analyzed for associations using p<0.005 combined with OR >1.8 or <0.5. We found that positive patch tests to weak allergens were common with 3 polymorphisms of CD80. CD80 is a co-stimulatory molecule on several cell types including innate lymphoid group 2 cells (ILC2). ILC2 presentation may bypass education in the local lymph node, explaining the association of antigens classified as non-sensitizers in LLN assay with CD80, and the absence of symptoms of immediate type hypersensitivity in many of these patients. Food handlers with hand dermatitis and patients with atopic dermatitis should be patch tested to allergens in foods (e.g. propylene glycol, vanillin, nickel, cobalt, and chromates) and instructed on dietary restriction of these allergens.

Indexed as

Allergic contact dermatitisAtopic dermatitisFood allergyInnate lymphoid cellsSystemic contact dermatitis

Identifiers

PMID40519868
PMCPMC12167014

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.