Evidence map›Paper›PMID 40519814›Full record

ReviewFrontiers in allergy2025

Enhancing allergy diagnosis: mass spectrometry as a complementary technique to the basophil activation test.

Nicole Wheeler, Miloslav Sanda, Lanya Rasool, Noha Elemary, Arda Alpan, Hamed Safi, Denise Loizou, Matthew Plassmeyer, Mikell Paige, Soren Ulrik Sonder and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicole WheelerDepartment of Chemistry & Biochemistry, College of Science, George Mason University, Fairfax, VA, United States.
Miloslav SandaMax-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Lanya RasoolDepartment of Chemistry & Biochemistry, College of Science, George Mason University, Fairfax, VA, United States.
Noha ElemaryDepartment of Chemistry & Biochemistry, College of Science, George Mason University, Fairfax, VA, United States.
Arda AlpanDepartment of Chemistry & Biochemistry, College of Science, George Mason University, Fairfax, VA, United States.
Hamed SafiDepartment of Chemistry & Biochemistry, College of Science, George Mason University, Fairfax, VA, United States.
Denise LoizouDepartment of Clinical Research, Amerimmune LLC, McLean, VA, United States.
Matthew PlassmeyerDepartment of Flowcytometry, Amerimmune LLC, McLean, VA, United States.
Mikell PaigeDepartment of Chemistry & Biochemistry, College of Science, George Mason University, Fairfax, VA, United States.
Soren Ulrik SonderDepartment of Flowcytometry, Amerimmune LLC, McLean, VA, United States.
Oral AlpanDepartment of Flowcytometry, Amerimmune LLC, McLean, VA, United States.
Michael GirgisCenter for Molecular Engineering, George Mason University, Manassas, VA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate diagnostic tools for allergic conditions are essential for effective treatment. Traditional methods, such as skin prick tests (SPT) and specific IgE measurements are widely used, but they have limitations in sensitivity and specificity for certain allergens. While the Basophil Activation Test (BAT) offers improved specificity, particularly for allergens such as peanuts and sesame, its practicality and accessibility remain challenges. Mass spectrometry (MS) has recently gained recognition as a promising complementary tool in allergy diagnostics, offering high analytical precision and the capability to detect a wide range of allergen-specific biomarkers. This review explores the integration of MS into allergy diagnostics, emphasizing its potential to enhance BAT applications, particularly for non-responders. We discuss the underlying mechanisms, recent research highlighting its efficacy, and the technical challenges that must be addressed for clinical adoption. Additionally, we examine the standardization requirements and ethical considerations necessary for MS to become a routine diagnostic tool. Finally, we consider the future of allergy diagnostics, highlighting how MS technology could contribute to more precise, personalized, and patient-centered care in allergy management.

Indexed as

BATdiagnosticsfood allergymass spectrometrysensitivityspecificity

Identifiers

PMID40519814
PMCPMC12162513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.