ArticleThe Pan African medical journal2025
Screening of endothelial dysfunction in rheumatoid arthritis in Black African subjects in the Physiology Department of the Faculty of Medicine of Dakar: a cross-sectional study.
Article in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: the vascular endothelium plays an essential role in many basic physiological vascular regulations. Endothelial dysfunction is the first stage of atherosclerosis. The latter would be the main basis of the cardiovascular events responsible for the high mortality of rheumatoid arthritis. The aim of this study was to screen for subclinical endothelial dysfunction in rheumatoid arthritis in a quick, easy and non-operator dependent way. Methods: this is a cross-sectional and prospective study conducted in the department of physiology and functional explorations from the Faculty of Medicine, of Pharmacy and of Odontostomatology (FMPOS) of the Cheikh Anta Diop University (UCAD) of Dakar in Senegal. Were excluded patients under 18 years and those with rheumatoid arthritis was associated with severe complications or other medical conditions or pregnancy. Therefore, we included subjects, aged 18 and over, with rheumatoid arthritis without clinically detectable cardiovascular complications. The reactive hyperemia index (RHI) was measured by an EndoPAT2000® (Itamar Medical Ltd-Israel) to explore endothelial function. Biochemical parameters were analyzed from fasting serum and plasma using an automated Abbott device. We used SPSS software to study endothelial dysfunction and the factors associated with it for simple and multiple linear regression calculations. Results: the mean age of the study population was 42.84 ± 12.80 years. The sex ratio (M/F) was 0.19. The reactive hyperemic index was significantly lower than the normal value in more than half of the patients with rheumatoid arthritis (11 subjects out of the 19 patients, i.e. 57.89%), indicating endothelial dysfunction in these patients. After Spearman correlation tests, a positive correlation was found between reactive hyperemic index and systolic blood pressure (rho=0.753 p=0.0002), mean blood pressure (rho= 0.660 p= 0.002), hs-CRP (rho= 0.486 p= 0.035) and uremia (rho= 0.476 p= 0.039). After a multiple linear regression test, a positive association was noted between the reactive hyperemia index and the systolic blood pressure (β 0.049, 95% CI [0.011 - 0.087]; p= 0.015). Conclusion: the endothelial dysfunction is a new concept in the management of rheumatoid arthritis. Screening and detection of this endothelial dysfunction in the subclinical state is possible thanks to new tools including EndoPATH2000. This could make it possible to predict the risk of cardiovascular events notably high blood pressure in general, and high systolic blood pressure in particular.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.