Evidence map›Paper›PMID 40519799›Full record

ArticleChemSystemsChem2025

Aqueous Synthesis of Membrane Lipids via Amide Formation between Amphiphilic Amines and Thioacids.

Jiyue Chen, Lalita Tanwar, Peng Ji, Roberto J Brea, Neal K Devaraj

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemSystemsChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiyue ChenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Lalita TanwarDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Peng JiDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Roberto J BreaBioinspired NanoChemistry (BioNanoChem) Group, CICA - Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, A Coruña, Spain.ORCID 0000-0002-0321-0156
Neal K DevarajDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8033-9973

Funding

Illuminating cellular dark matter through the development of novel chemical toolsR35GM141939 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVARAJ, NEAL KRISHNA · 2021 to 2025
$2.2M
NIGMS NIH HHS R35 GM141939
6 · The paper itself

Abstract

Protocell membranes were likely formed through primitive metabolic reactions that synthesized more complex membrane lipid species from simpler precursors. Thioacids have been shown to be prebiotically plausible and chemoselective

Indexed as

amphiphiliclipidmembranethioacidvesicle

Identifiers

PMID40519799
PMCPMC12161896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.