Evidence map›Paper›PMID 40519746›Full record

ArticleGenetics in medicine open2025

Pharmacogenomic testing implementation: Tertiary care center experience and results of a pilot of 512 patients.

Dana Bakheet, Hana Al Alshaykh, Ghadi Askar, Sateesh Maddirevula, Samya Hagos, Nasir Hamad Alshahrani, Midrar Alhusseini, Amani Moharram, Faries Algadhi, Osama Alswailim and 12 more

Abstract read
In one paragraph

Article in Genetics in medicine open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Dana BakheetKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Hana Al AlshaykhKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ghadi AskarCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Sateesh MaddirevulaKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Samya HagosKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Nasir Hamad AlshahraniKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Midrar AlhusseiniKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Amani MoharramKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Faries AlgadhiKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Osama AlswailimKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Moatasem AlsulaimKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Bandar AlamroKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Fadl Elmula Mohamed Fadl ElmulaKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Bahadur KhanKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ahmed AlmustafaKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ahmed AlshehriKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Dimpna BrotonsKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Fahad AlajlanKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Mohammed AlnahedhKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Abdullah AlsuwaidanKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Salah BazKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ahmed AlfaresKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Pharmacogenomic (PGx) testing has proven significant clinical utility in minimizing adverse drug reactions and maximizing therapeutic effects. This report is a proof of concept of the clinical implementation of PGx testing at a tertiary care hospital in Riyadh, Saudi Arabia. Methods: In collaboration with different departments, we implemented the PGx testing clinical service into our electronic health record cerner for heart and neurology centers patients. We used the PharmacoScan microarray-based test to perform genotyping. Results: To date, 512 patients have been tested. 97.5% of all patients have at least 1 gene with altered function. Among those patients, Conclusion: Our work describes the successful implementation of PGx testing in clinical practice and encourages further research on improving patient outcomes. Moreover, we describe the major challenges at each step of our approach, which provides our institute and others with lessons and insights on implementing PGx testing into clinical practice.

Indexed as

GenomicsPersonalized medicinePharmacogenetics (PGx)Pharmacogenomics (PGx)Precision medicine

Identifiers

PMID40519746
PMCPMC12166389

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.