ArticleTranslational pediatrics2025
Comparison of readout-segmented echo-planar imaging and single-shot echo-planar imaging in the fetal brain.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The diagnostic value of diffusion-weighted imaging (DWI) in fetal brain imaging has been established for various brain lesions, yet conventional DWI single-shot echo-planar imaging (SS-EPI) suffers from distortion and artifacts. Readout Segmentation of Long Variable Echo-trains (RESOLVE) is an advanced technology that can produce better image quality than SS-EPI. This study was aimed to evaluate the clinical effectiveness of RESOLVE and SS-EPI in visualizing the fetal brain. Methods: We performed RESOLVE and SS-EPI on 190 fetal brains from December 2019 to December 2021, and two radiologists reviewed the two datasets separately. Qualitative analyses were conducted in susceptibility-related change, image distortion, lesion conspicuity, and overall image quality with a 5-point Likert scale. Inter-reader agreement was measured using a Cohen kappa statistic. The apparent diffusion coefficient (ADC) and signal-to-noise ratio (SNR) of the two sequences in bilateral centrum semiovales were measured and compared. Results: The readers had good agreement with their scores (k>0.6). All the subjective parameters between the two sequences showed statistical significance (all P<0.05). The respective mean (range) scores for SS-EPI and RESOLVE were 4 (3.5, 4) and 4.5 (4, 4.5) for susceptibility-related change, 4.5 (4, 4.5) and 5 (4.5, 5) for image distortion, 4 (3.5, 4.5) and 4.5 (4, 5) for lesion conspicuity, and 4 (3.5, 4) and 4.5 (4, 4.5) for overall image quality. The ADC values in the centrum semiovale did not differ between the two sequences (P=0.64). Last, the SNR was 45.53 for SS-EPI, significantly higher than that of RESOLVE at 35.57 (P<0.001). Conclusions: In terms of distortion, susceptibility-related changes, and lesion conspicuity, RESOLVE was better at visualizing the fetal brain than SS-EPI. However, SS-EPI scored better than RESOLVE in the SNR.
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