ArticleTransplantation direct2025
The Impact of Normothermic Machine Perfusion on Biliary Complications in Donation After Circulatory Death Donor Liver Transplantation.
Article in Transplantation direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Normothermic Perfusion Versus Static Cold Storage in Liver Transplantation: A Meta-Analysis of Randomized Trials.Clinical transplantation · 2025Pooled it
- A Common Language for Post-Transplant Anastomotic Biliary Strictures: Standardized Endoscopic Outcome Definitions and a Failure-Mode Roadmap.Medicina (Kaunas, Lithuania) · 2026Review
- Re-Evaluating Donor-Recipient Risk Scores in the Machine Perfusion Era Using a Large Multicenter Cohort: Do Traditional Predictive Models Still Apply?Clinical transplantation · 2026Article
- Different Knots, Same Outcome: Evaluating the Role of Surgical Technique on Biliary Anastomotic Strictures After Liver Transplantation.World journal of surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The incidence of ischemic cholangiopathy (IC) in liver transplant (LT) patients from donation after circulatory death (DCD) has been observed to be higher compared with those from donation after brain death (DBD). It has been reported that the normothermic machine perfusion (NMP) technique was associated with lower rates of IC. However, the effect of NMP on anastomotic biliary complications remains unclear. Methods: A total of 450 LTs performed between January 2019 and December 2023 were analyzed in a retrospective study. The primary outcome included biliary complications within 180 d after LT and those classified by type (bile leak, stricture, or IC). Risk factors for biliary complications were compared between the NMP group and the non-NMP group within both the DBD and DCD groups. Results: The incidence of IC was higher in the DCD without NMP group at 17.5% (10/57), compared with the DCD with NMP group (0%). DCD was independently associated with the development of biliary complications by all causes after LT (odds ratio, 2.29 [95% confidence interval, 1.29-4.07], Conclusions: Although NMP might prevent IC, it did not reduce the risk of biliary complications regardless of donor type. Blood circulation to the biliary system may not be adequate, leading to anastomotic biliary complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.