Evidence map›Paper›PMID 40519668›Full record

ArticleFrontiers in aging2025

Oropharyngeal detection of specific gut-derived Enterobacterales is associated with increased respiratory infection risk in older adults.

Sophie J Miller, Frank Zhang, Steven L Taylor, Andrew P Shoubridge, Erin Flynn, Egi Vasil, Richard J Woodman, Lito E Papanicolas, Geraint B Rogers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophie J Miller *Microbiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Frank Zhang *Microbiology and Infectious Diseases, SA Pathology, Adelaide, SA, Australia.
Steven L TaylorMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Andrew P ShoubridgeMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Erin FlynnMicrobiology and Infectious Diseases, SA Pathology, Adelaide, SA, Australia.
Egi VasilMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Richard J WoodmanFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Lito E Papanicolas *Microbiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Geraint B Rogers *Microbiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory tract infections (RTI) are a major contributor to morbidity and mortality in later life. RTI risk factors in older populations, including declining general health, altered airway physiology, and increased pharmaceutical exposures, also contribute to changes in the oropharyngeal (OP) microbiota. We sought to investigate whether such changes predict future incidence of RTI. OP microbiota characteristics were measured in 190 residents of long-term aged care. Fifty-four participants (28.4%) experienced one or more study-defined RTIs during the 12-month follow-up period, of which 28 (14.7%) occurred within 90 days of sample collection. OP microbiota composition was significantly associated with days to RTI event (F = 1.74, R

Indexed as

Enterobacteralesmicrobiomenursing homesolder peoplepneumonia

Identifiers

PMID40519668
PMCPMC12162913

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.