ArticleOpen forum infectious diseases2025
Impact of Substance Use Disorders on Outcomes of Medically Insured Persons Receiving Multiweek Outpatient Parenteral Antimicrobial Therapy: a Claims-based Cohort Study From 2015 to 2020.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Outpatient parenteral antimicrobial therapy (OPAT) is often withheld from individuals with substance use disorder (SUD), despite evidence suggesting similar outcomes. We investigated this using a large, nationwide claims database. Methods: We analyzed Merative MarketScan (2015-2020) data to identify adults treated with intravenous vancomycin, daptomycin, nafcillin, oxacillin, or cefazolin for ≥7 days after hospitalization. Patients with end-stage renal disease or Results: Among 5903 patients, 18% had SUD. These patients were younger, less often male, and less likely discharged home. Unadjusted rates of 90-day readmission (40.1% vs 32.5%, Conclusions: SUD was not independently associated with increased 90-day readmission or CVC event risk, but was a significant risk factor for overdose, supporting harm reduction approaches over exclusion from OPAT based on SUD status.
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