ArticleAdvanced biomedical research2025
Biogenic Ag-Cu Nanoparticles Synthesized with Extract of
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The anticancer action of biogenic Ag-Cu nanoparticles (NPs) using Materials and Methods: XRD, FTIR, EDAX, FESEM, and TEM were used to illustrate the Ag-Cu NPs. The PC-3 and LNCaP cell lines were used to test the anticancer ability of Ag-Cu NPs. The cytotoxicity was assessed by MMT and flow cytometry. Apoptotic and metastatic-promoting gene expressions were evaluated by real-time PCR. ROS generation was measured. Results: NPs are spherical and their average size was 12 ± 9.7 nanometers. The EDAX result indicated the presence of Ag, Cu, and C. The XRD results revealed the NPs' crystalline structure. The results demonstrated a remarkable antiproliferative effect of the nanoparticles, with IC50 values of 15.43 μg/mL for PC-3 and 7.64 μg/mL for LNCaP. The Ag-Cu NPs exhibited a tendency to trigger apoptosis. This was confirmed by analyzing apoptosis-related gene expression. The apoptotic influence of Ag-Cu NPs was suggested to be critical when compared to the control and extract-treated groups by the up-regulation of Conclusions: The study suggested
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