ArticleFrontiers in pediatrics2025
Construction of a nomogram for predicting serum vitamin D deficiency in children/adolescents with new-onset type 1 diabetes: a single-center study in China.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The vitamin D-type 1 diabetes (T1D) association has been debated in public health. The purpose of this study was to develop a vitamin D deficiency prediction model and investigate vitamin D deficiency risk factors in children and adolescents with new-onset T1D. Methods: A single-centre, retrospective analysis of paediatric patients (1-18 years) with new-onset T1D and initial 25-hydroxyvitamin D assessments was performed at a tertiary hospital in China between January 2020 and July 2024 ( Results: The prevalence rate of serum vitamin D deficiency among patients with new-onset T1D was 26.35% (93/353). Multivariate logistic regression analysis revealed that minority status (X1), weight (X2), diabetic ketoacidosis severity (X3), serum vitamin D testing season (X4), free triiodothyronine (X5), and high-density lipoprotein (X6) were closely associated with serum vitamin D deficiency development in children/adolescents with new-onset T1D ( Conclusions: The established risk prediction model has good efficacy, providing a reference for screening high-risk vitamin D deficiency groups among children/adolescents with new-onset T1D and taking preventive and protective measures. The nomogram was developed based on a single-center cohort in China, and its generalizability needs further validation in more extensive populations.
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