Evidence map›Paper›PMID 40519450›Full record

ArticleCureus2025

Preimplantation Genetic Testing for Aneuploidy in Recurrent Pregnancy Loss: A Fertility Success Story.

Apostolos C Ziogas, Polyxeni-Natalia Liasidi, Afroditi Katouna, Anastasia Koutsouni, Konstantina Faki, Evangelia Karangeli, Efthymia Thanasa, Anna Thanasa, Ioannis Thanasas, Emmanouil M Xydias

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Apostolos C ZiogasSchool of Health Sciences, Faculty of Medicine, University of Thessaly, Larissa, GRC.
Polyxeni-Natalia LiasidiDepartment of Obstetrics and Gynecology, Agios Dimitrios General Hospital, Thessaloniki, GRC.
Afroditi KatounaIVF Clinic, IASO Thessalias, Larissa, GRC.
Anastasia KoutsouniIVF Clinic, IASO Thessalias, Larissa, GRC.
Konstantina FakiOutpatient Gynecology Clinic, OB/GYN SPOT, Larissa, GRC.
Evangelia KarangeliOutpatient Gynecology Clinic, OB/GYN SPOT, Larissa, GRC.
Efthymia ThanasaDepartment of Histology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Anna ThanasaDepartment of Anatomy, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Ioannis ThanasasDepartment of Obstetrics and Gynecology, General Hospital of Trikala, Trikala, GRC.
Emmanouil M XydiasDepartment of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) is a challenging condition in the field of assisted reproduction, with various potential causes that may be maternal or fetal in origin. When fetal factors are involved, preimplantation genetic testing for aneuploidy (PGT-A) serves as an effective method to assess embryo genetic integrity, helping identify viable embryos with a higher likelihood of implantation and live birth. This report describes the case of a 30-year-old woman with a history of recurrent miscarriages. After a comprehensive evaluation of possible maternal and paternal factors, and three additional pregnancy losses confirmed to be due to aneuploidy, she underwent in vitro fertilization combined with PGT-A. This resulted in the identification of seven euploid blastocysts. A single embryo transfer led to an ongoing pregnancy, highlighting the clinical utility of PGT-A in the management of RPL.

Indexed as

assisted reproduction technologyeuploidyinfertilitykaryotypepreimplantation genetic testing for aneuploidy (pgt-a)recurrent pregnancy loss

Identifiers

PMID40519450
PMCPMC12163842

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.