Evidence map›Paper›PMID 40519390›Full record

ReviewCureus2025

Artificial Intelligence (AI)-Driven Approaches to Manage Postoperative Pain, Anxiety, and Psychological Outcomes in Surgical Patients: A Systematic Review.

Sachin Agrawal, Rana Veer Samara Sihman Bharattej Rupavath, Priji Prasad Jalaja, Azhar Ushmani, Aashish Mishra, Naga Venkata Satish Babu Bodapati

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sachin AgrawalDepartment of Information Technology, Synechron, Charlotte, USA.
Rana Veer Samara Sihman Bharattej RupavathDepartment of Business Administration, National Louis University, Tampa, USA.
Priji Prasad JalajaDepartment of Surgery, Emory University, Atlanta, USA.
Azhar UshmaniDepartment of Information Security, Amazon Web Service (AWS), Dallas, USA.
Aashish MishraDepartment of Computer and Information Science, Eastern Kentucky University, Richmond, USA.
Naga Venkata Satish Babu BodapatiDepartment of Psychiatry and Behavioral Sciences, Sunshine Behavioral Health Services Inc, Bakersfield, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative pain, anxiety, and psychological distress significantly impact surgical recovery, yet conventional management strategies often lack personalization. Artificial intelligence (AI) has emerged as a transformative tool in perioperative care, offering potential solutions through predictive analytics, real-time monitoring, and tailored interventions. This systematic review synthesizes evidence on AI-driven approaches for improving postoperative pain, anxiety, and psychological outcomes in surgical patients. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive search of PubMed, Institute of Electrical and Electronics Engineers (IEEE) Xplore, Scopus, Web of Science, and Cochrane Library up to April 2025. Ten studies met the inclusion criteria. Risk of bias was assessed using the revised Cochrane risk of bias tool for randomized trials (ROB 2) and Risk Of Bias In Non-randomized Studies-of Interventions (ROBINS-I) for non-randomized studies. Data were narratively synthesized by AI applications (e.g., nociception monitoring, robotics, machine learning (ML)) and outcomes (pain, anxiety, psychological metrics). AI interventions demonstrated efficacy in reducing postoperative pain (e.g., nociception level (NOL)-guided analgesia lowered pain scores by 33% vs. standard care) and anxiety (e.g., interactive robots reduced pediatric preoperative anxiety). ML models predicted pain severity (area under the curve (AUC) up to 0.75) and complications (AUC 0.84) but showed lower accuracy for readmissions (AUC 0.66). Automated psychological interventions reduced opioid use by 36.5%. Limitations included small sample sizes (12 to 201 participants), heterogeneity in AI methods, and short follow-up durations. AI shows promise in personalizing perioperative care, particularly for pain and anxiety management, though standardization and larger trials are needed. Future research should prioritize robust validation, long-term outcomes, and integration into clinical workflows to translate AI's potential into routine practice.

Indexed as

anxietyartificial intelligenceperioperative carepostoperative painpsychological outcomes

Identifiers

PMID40519390
PMCPMC12167618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.