Evidence map›Paper›PMID 40519363›Full record

ArticleBioactive materials2025

Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects.

Xiaoyang Liu, Jia Dong, Zhongshu Wu, Jiarong Cui, Yixin Zheng, Min Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoyang LiuEye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Jia DongZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, China.
Zhongshu WuZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, China.
Jiarong CuiInstitute of Translational Medicine, Zhejiang University, Hangzhou, 310009, China.
Yixin ZhengThe First affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Min ZhouEye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gouty arthritis (GA) is a type of inflammatory arthritis caused by the deposition of monosodium urate crystals. Current clinical therapies fail to simultaneously reduce uric acid (UA) levels and alleviate inflammation. Previous studies have demonstrated that Euglena (Eug) polysaccharides can effectively adsorb UA. Colchicine (Col), the most prescribed medication for GA, exhibits anti-inflammatory effects but is associated with significant side effects. Here, we developed an oral microalgae-based hydrogel system (Eug-Col@Fucar) utilizing Fucar to load the Eug-Col complex, aiming to synergistically reduce UA levels and alleviate inflammation in GA treatment. Eug-Col@Fucar regulated release characteristics and enhanced intestinal retention, thereby mitigating the side effects associated with oral Col. The oral administration of Eug-Col@Fucar could inhibit the progression of GA by eliminating reactive oxygen species, reprogramming the inflammatory microenvironment to promote cell polarization towards M2-like anti-inflammatory cells, inhibiting the NLRP3-IL-1β pathway, and reducing the expression of pro-inflammatory factors. Additionally, Eug-Col@Fucar improved bile acid metabolism

Indexed as

Alleviated side effectsAnti-inflammationColchicineDrug deliveryGouty arthritisMicroalgaeUric acid

Identifiers

PMID40519363
PMCPMC12162043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.