ArticleLe infezioni in medicina2025
High Mortality and Antimicrobial Resistance: Challenges of Bloodstream Infections in Liver Transplant Recipients.
Article in Le infezioni in medicina, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Multidrug resistant bacterial infection in liver transplant recipients: A Deterrent and obstacle.Pakistan journal of medical sciences · 2026Article
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Bloodstream infections (BSIs) are one of the most frequent complications among liver transplant recipients and are associated with a markedly increased risk of death. Our study aims to define the incidence, epidemiology and clinical characteristics of BSIs after liver transplantation (LT) and to investigate risk factors related to 30-day mortality. Methods: We considered all patients who underwent LT at the Università Politecnica delle Marche of Ancona for up to 10 years and selected those who experienced at least one episode of BSI. Results: Out of 601 LT recipients, 96 had at least one episode of BSI. Most BSIs occurred within the first month post-transplantation. Central vascular catheter infections were the most frequent source, followed by surgical site infections, pneumonia, and urinary tract infections. Overall, we isolated 102 microorganisms: 66% were Gram-negative bacteria, 30% Gram-positive bacteria and 4% fungi. High rates of antimicrobial resistance were observed among both Gram-negative (34%) and Gram-positive bacteria (84%).Thirty-day mortality was 26%, with septic shock (HR 226.980 [CI 95% 5.083-10135.347], p=0.005), the absence of invasive procedures within 72 hours before BSI onset (HR 88.567 [CI 95% 2.484-357.754], p=0.014), white blood cell count ≥ 2,500/mmc (HR 34.948 [CI 95% 1.568-778.750], p=0.025), creatinine >1.02 mg/dl (HR 13.982 [CI 95% 1.487-131.485], p=0.021] and hypoalbuminemia (HR 24.775 [CI 95% 1.371-447.744], p=0.030) being significant risk factors. Conclusions: This study provides detailed insights into post-transplant BSIs, highlighting the alarming rates of antimicrobial resistance, thereby suggesting a major effort to rationalize the use of antimicrobial therapy.
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