Evidence map›Paper›PMID 40519238›Full record

ArticleCerebral circulation - cognition and behavior2025

The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial.

Liz R van Hout, Justine Moonen, Annebet E Leeuwis, Juliette van Alphen, Mathijs Dijsselhof, Raquel P Amier, Frederik Barkhof, Esther E Bron, Doeschka A Ferro, Alexander G J Harms and 11 more

Abstract read
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In one paragraph

Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Liz R van HoutAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Justine MoonenAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Annebet E LeeuwisAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Juliette van AlphenAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Mathijs DijsselhofAmsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Raquel P AmierDepartment of Cardiology, VU University Medical Centre, Amsterdam, The Netherlands.
Frederik BarkhofAmsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Esther E BronBiomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, The Netherlands.
Doeschka A FerroDepartment of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Alexander G J HarmsBiomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, The Netherlands.
Rosalie J HuijsmansDepartment of Rehabilitation, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.
Joost P A KuijerDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, VU University Medical Centre, Amsterdam, The Netherlands.
Sanne KuipersDepartment of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Matthias J P van OschC.J. Gorter MRI Centre, Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
Niels D PrinsAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Marc B RietbergDepartment of Rehabilitation, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.
Charlotte E TeunissenAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Henk Jan MutsaertsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Geert Jan BiesselsDepartment of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Wiesje M van der FlierAlzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Heart-Brain Connection Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic exercise may improve cerebral perfusion and may thereby attenuate, or delay, cognitive decline. Excersion-VCI aimed to evaluate the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment (VCI). This Randomized Controlled Trial included non-demented adults ≥50 years diagnosed with VCI. Patients were randomly assigned either home-based aerobic interval training (exercise group) or information sessions (control group). Primary outcome was change in Arterial Spin Labelling MRI grey matter cerebral perfusion from baseline to 14-week follow-up. Per-protocol analysis was performed in patients who completed the follow-up. Secondary outcomes were VO

Indexed as

Arterial spin labellingCerebral blood flowcognitionExerciseRandomised clinical trialVascular cognitive impairment

Identifiers

PMID40519238
PMCPMC12166751

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.