Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis.

Qigan Gao, Yuehua Yang, Haoxiang Yang, Hongyuan Jiang

Abstract read

In one paragraph

Article in Mechanobiology in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qigan GaoCAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Yuehua YangCAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Haoxiang YangCAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Hongyuan JiangCAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyosin feedback. The recently developed 3D vertex model demonstrates that crypt curvature modulates actomyosin localization via mechanosensitive pathways, creating two stable morphological states-bulged or budded-depending on mechanical history. This model advances beyond static vertex models by incorporating epithelial thickness variations and lumen pressure effects, explaining previously unresolved phenomena like irreversible crypt budding and snap-through transitions. The findings establish a new framework for understanding mechanical decision-making in epithelial tissues, with implications for organoid engineering and developmental biology.

Indexed as

Epithelial mechanicsIntestinal organoidsMechanical bistabilityMorphogenesisVertex model

Identifiers

PMID40519214

DOI10.1016/j.mbm.2025.100134

PMCPMC12164025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.