Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model.

F Boscolo Sesillo, H Manoochehri, P Duran, E Zelus, K L Christman, M Alperin

Abstract read

In one paragraph

Article in npj women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F Boscolo Sesillo *Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, University of California, San Diego, San Diego, CA USA.

H Manoochehri *Division of Biological Sciences, University of California, San Diego, La Jolla, CA USA.

P DuranShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA USA.

E ZelusShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA USA.

K L ChristmanSanford Consortium for Regenerative Medicine, La Jolla, CA USA.

M AlperinDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, University of California, San Diego, San Diego, CA USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic floor muscle (PFM) recovery following childbirth is essential for preserving pelvic floor function. Despite this, the impact of parturition and lactation on pelvic muscle stem cells (MuSCs), indispensable for skeletal muscle maintenance and regeneration, remains unknown. We determined that vaginal delivery does not cause mechanical injury of the rat PFMs, enabling us to uncouple the effects of lactation on muscle homeostasis from PFM regeneration following simulated birth injury (SBI). Tibialis anterior (TA) served as non-pelvic control. This novel study demonstrates that in the absence of birth injury, lactation blocks MuSC proliferation in PFM and TA, suggesting that postpartum systemic milieu affects MuSCs in pelvic and non-pelvic muscles. In contrast, SBI negated the inhibitory effect of lactation on MuSCs in PFM but not in TA, indicating that local signals released by the injured muscle overcome systemic inhibitory effects of lactation, which persist in muscles remote from the site of injury.

Indexed as

PhysiologyReproductive biology

Identifiers

PMID40519212

DOI10.1038/s44294-025-00079-7

PMCPMC12162343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.