ArticleJournal of the American Heart Association2025
Imaging-Based Brain Frailty Predicts Unfavorable Outcomes in Acute Ischemic Stroke.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of Brain Frailty in Stroke Outcomes: A Systematic Review.Neurology international · 2026Review
- Age-Related Brain Atrophy Mediates a Composite Outcome of One-Year Ischemic Stroke Recurrence and All-Cause Mortality Through YKL-40-Related Inflammatory Pathways: A Structural Equation Model.Translational stroke research · 2026Article
- Multi-dimensional MRI representation and privileged learning approaches to functional outcome prediction for ischemic stroke patients.NPJ digital medicine · 2026Article
- The association of high-sensitivity C-reactive protein-triglyceride glucose index with functional outcome in elderly patients with acute ischemic stroke undergoing intravenous thrombolysis.Frontiers in neurology · 2026Observational
- Automated brain atrophy quantification from clinical MRI predicts early neurological deterioration in anterior choroidal artery territory infarction.Frontiers in neuroscience · 2025Article
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21 authors.
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Abstract
backgroundBrain frailty is characterized by imaging biomarkers of chronic cerebrovascular injury. Whether brain frailty improves the prediction of acute ischemic stroke complications and prognosis requires further study.
methodsThis multicenter, retrospective study included patients with acute ischemic stroke due to large-vessel occlusion in the anterior circulation. All patients underwent magnetic resonance imaging within 7 days of stroke onset, measuring subcortical and cortical atrophy and white matter hyperintensity as indicators of brain frailty. Multivariable logistic regression analyses and receiver operating characteristic curve analyses were used to assess the association and predictive value of brain frailty with complications and unfavorable clinical outcome (90-day modified Rankin Scale score, 3-6).
resultsThe study included 1090 patients with a median age of 64 (interquartile range, 55-73) years and a median National Institutes of Health Stroke Scale score of 9 (interquartile range, 4.5-15). Multivariable logistic regression analysis showed that independent risk factors for the unfavorable clinical outcome included: National Institutes of Health Stroke Scale score (odds ratio [OR], 1.09 [95% CI, 1.06-1.11]), blood glucose (OR, 1.18 [95% CI, 1.11-1.26]), infarct volume (OR, 1.43 [95% CI, 1.29-1.60]), subcortical atrophy (OR, 1.16 [95% CI, 1.10-1.23]), severe cortical atrophy (OR, 2.31 [95% CI, 1.04-5.15]), and severe white matter hyperintensity (OR, 3.63 [95% CI, 1.91-6.89]). However, brain frailty was not significantly associated with acute ischemic stroke complications (malignant cerebral edema, parenchymal hemorrhage). Including brain frailty indicators in the model significantly improved its unfavorable clinical outcome predictive power (area under the receiver operating characteristic curve increased from 0.762 to 0.822;
conclusionsBrain frailty was significantly associated with the unfavorable clinical outcome. Brain frailty indicators contributed to the predictive efficacy, regardless of treatment modality.
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