ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Picoliter-Volume Isothermal Titration Calorimetry Using Parylene Chip Calorimeter Integrated with on-Demand Droplet Microfluidics.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Picoliter-Volume Isothermal Titration Calorimetry Using Parylene Chip Calorimeter Integrated with on-Demand Droplet Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Isothermal titration calorimetry (ITC) is a gold-standard technique for directly quantifying biomolecular interactions, but its broader applicability is limited by large sample consumption and low throughput. To address these challenges, considerable efforts are made to develop chip calorimeter systems. Here, a high-sensitivity chip calorimeter integrated with on-demand droplet microfluidics is presented, capable of performing ITC with picoliter-volume samples. The device combines vanadium pentoxide thermistors, vacuum-insulated parylene microfluidics, and multilayer Polydimethylsiloxane microfluidics to achieve precise thermal measurement and fluidic control. On-demand generation and merging of titrant and titrand droplets enable accurate control of molar ratios for droplet-based titration. The chip calorimeter achieves a temperature resolution of 14.9 µK and a power resolution of 2.31 nW. The platform is validated by measuring the binding interaction between 18-crown-6 and barium chloride, with extracted thermodynamic parameters in good agreement with conventional ITC. This work advances miniaturized ITC technology by providing a scalable and efficient platform for quantitative biochemical analysis, particularly in sample-limited and high-throughput applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.