Evidence map›Paper›PMID 40518991›Full record

ArticleAddiction (Abingdon, England)2025

Associations of plasma sex-related hormone and protein levels and alcohol dependence.

Ada Man-Choi Ho, Jennifer R Geske, Vanessa K Pazdernik, T Cameron Waller, Anthony Batzler, Stacey J Winham, Victor M Karpyak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ada Man-Choi HoDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0003-4989-8782
Jennifer R GeskeDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Vanessa K PazdernikDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
T Cameron WallerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Anthony BatzlerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Stacey J WinhamDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Victor M KarpyakDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-9552-6130

Funding

Pharmacogenomics of Acamprosate Treatment Outcome (Supplement)U01AA027487 · NIAAA · MAYO CLINIC ROCHESTER · PI BIERNACKA, JOANNA M, KARPYAK, VICTOR M. · 2018 to 2023
$3.7M
The Mayo Clinic Center for Individualized Treatment of Alcohol DependenceP20AA017830 · NIAAA · MAYO CLINIC ROCHESTER · PI CHOI, DOO-SUP · 2009 to 2010
$2.5M
IMPACT OF SEX-RELATED HORMONE LEVELS AND GENETIC VARIATION ON ALCOHOL USE DISORDERS AND RELATED PHENOTYPES IN MALES AND FEMALESR21AA026875 · NIAAA · MAYO CLINIC ROCHESTER · PI KARPYAK, VICTOR M., WINHAM, STACEY J · 2019 to 2020
$417k
NIAAA NIH HHS P20 AA017830NIAAA NIH HHS P20AA017830-01NIAAA NIH HHS R21 AA026875NIAAA NIH HHS R21AA026875NIAAA NIH HHS U01 AA027487NIAAA NIH HHS U01AA027487Samuel C. Johnson Genomics of Addiction Program at Mayo Clinic
6 · The paper itself

Abstract

BACKGROUND AND

aimsSex-related hormones and proteins may underlie sex differences in alcohol use disorder characteristics and consequences. Previous reports suggest steroid sex hormones may influence alcohol consumption behaviors while proteins that regulate their circulation levels are rarely investigated. Following up on our earlier study of individual sex-related hormones' associations with alcohol dependence (AD), this study measured the associations between the combinations of sex-related hormones and proteins and AD in a larger sample.

designSex-stratified case-control comparison and clustering of plasma sex-related hormone and protein levels, plus a genome-wide association study on the AD-associated hormone and protein combinations.

settingAddiction treatment programs in the United States.

participantsFour hundred treatment-seeking recently abstained AD patients (median = 24.5 days) and 388 age-and-sex-matched controls from a community biobank (male:female ≈ 2:1). MEASUREMENTS: Plasma levels of total testosterone, estrone (E1), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone binding globulin (SHBG) and albumin.

findingsIn males, we found higher E2 [β = 0.13, P

conclusionsThree sex-related hormone and protein signatures appear to be associated with alcohol dependence in each sex. Peripheral levels of sex-related hormones and proteins, as well as their combinations, could be altered in people with alcohol dependence who have abstained for a few weeks compared with controls, and such differences may be sex-specific.

Indexed as

AlcoholismGonadal Steroid HormonesAdultCase-Control StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneGenome-Wide Association StudyHumansLuteinizing HormoneMaleMiddle AgedSerum AlbuminSex FactorsSex Hormone-Binding GlobulinEstradiolEstroneFollicle Stimulating HormoneGonadal Steroid HormonesLuteinizing HormoneSerum AlbuminSex Hormone-Binding GlobulinTestosteronealcohol dependencealcohol use disorderestrogensGWASprogesteronesex hormone binding globulinsex hormonestestosterone

Identifiers

PMID40518991
PMCPMC12426352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.