Evidence map›Paper›PMID 40518954›Full record

ArticleJournal of Parkinson's disease2025

Reduced expression of

Banya Pak, Chaeeun Kim, Seung-Hae Kwon, Joon-Kyu Lee, Sang-Hak Jeon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Banya PakDepartment of Science Education, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0001-5437-652X
Chaeeun KimDepartment of Science Education, Seoul National University, Seoul, Republic of Korea.
Seung-Hae KwonKorea Basic Science Institute, Seoul Center, Seoul, Republic of Korea.ORCID 0000-0001-5554-9015
Joon-Kyu LeeDepartment of Science Education, Seoul National University, Seoul, Republic of Korea.
Sang-Hak JeonDepartment of Science Education, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0001-7519-9147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundParkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons. While abnormal protein aggregation has been classically implicated in PD, increasing evidence suggests that lipid dysregulation may also contribute to neuronal vulnerability. Recent studies have begun to link abnormal phosphatidylserine (PS) metabolism to mitochondrial impairment and dopaminergic neuron loss in PD, yet the underlying cellular mechanisms remain poorly defined.ObjectiveThis study aimed to determine how impaired PS synthesis in cortex glia affects mitochondrial function, oxidative stress, and dopaminergic neuron survival, using a

Indexed as

Cerebral CortexDopaminergic NeuronsDrosophila ProteinsNeurogliaAnimalsAnimals, Genetically ModifiedCell DeathDisease Models, AnimalDrosophilaGene Knockdown TechniquesMitochondriaOxidative StressParkinson DiseaseDrosophila Proteinscortex gliadopaminergic cellsmitochondrial dysfunctionParkinson's diseasephosphatidylserine

Identifiers

PMID40518954
PMCPMC13347493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.