Evidence map›Paper›PMID 40518825›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Presence of Alzheimer's disease variants in circular RNA of

Ian P Johnson, Tia M Peterson, Kathryn Gudsnuk, C Dirk Keene, Thomas D Bird, Suman Jayadev, Paul N Valdmanis, Meredith M Course

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ian P JohnsonDepartment of Molecular Biology, Colorado College, Colorado Springs, CO, USA.ORCID 0009-0003-2472-9277
Tia M PetersonDepartment of Molecular Biology, Colorado College, Colorado Springs, CO, USA.ORCID 0009-0000-0645-5004
Kathryn GudsnukAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-1507-2379
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5291-1469
Thomas D BirdDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-9598-3529
Suman JayadevDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-3164-9665
Paul N ValdmanisDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-8840-6969
Meredith M CourseDepartment of Molecular Biology, Colorado College, Colorado Springs, CO, USA.ORCID 0000-0002-6412-4438

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
NIA NIH HHS P30 AG066509
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are emerging as a promising object of study in Alzheimer's disease (AD) pathogenesis. Expression differences in circRNAs have been correlated with disease; however, the presence of pathogenic variants has not been observed until now. Here, we examine circRNAs derived from two AD-related genes, presenilin 1 (

Indexed as

Alzheimer DiseasePresenilin-1Presenilin-2RNA, CircularAgedFemaleHumansMaleMiddle AgedPrefrontal CortexPresenilin-1Presenilin-2PSEN1 protein, humanPSEN2 protein, humanRNA, CircularAlzheimer's diseasecircular RNAneurodegenerative diseasesnoncoding RNApresenilin 1presenilin 2single nucleotide polymorphismSNPs

Identifiers

PMID40518825
PMCPMC12994479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.