Evidence map›Paper›PMID 40518819›Full record

ArticleJournal of the American Chemical Society2025

Resistance Gene-Guided Genome Mining Reveals RPL10 as the Target of Ligustrone A.

Danielle A Yee, Ross D Overacker, Michelle F Grau, Amber Cornelius, Adrianne Pigula, Daniel Mummau, Thomas Pavey, Cynthia Bailey, Clarence Hue Lok Yeung, Lawrence S Hon and 6 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. ARTS-DB 2.0: an expanded database for target-directed genome mining across bacteria and fungi.Database : the journal of biological databases and curation · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Danielle A YeeHexagon Bio, Menlo Park, California 94025, United States.
Ross D OverackerHexagon Bio, Menlo Park, California 94025, United States.
Michelle F GrauHexagon Bio, Menlo Park, California 94025, United States.
Amber CorneliusHexagon Bio, Menlo Park, California 94025, United States.
Adrianne PigulaHexagon Bio, Menlo Park, California 94025, United States.
Daniel MummauHexagon Bio, Menlo Park, California 94025, United States.
Thomas PaveyHexagon Bio, Menlo Park, California 94025, United States.
Cynthia BaileyHexagon Bio, Menlo Park, California 94025, United States.
Clarence Hue Lok YeungHexagon Bio, Menlo Park, California 94025, United States.
Lawrence S HonHexagon Bio, Menlo Park, California 94025, United States.
Joseph E SprakerHexagon Bio, Menlo Park, California 94025, United States.
Sheena LiHexagon Bio, Menlo Park, California 94025, United States.
Bruno PerlattiHexagon Bio, Menlo Park, California 94025, United States.ORCID 0000-0002-4403-3387
Samuel K Oteng-PabiHexagon Bio, Menlo Park, California 94025, United States.
Henry H LeHexagon Bio, Menlo Park, California 94025, United States.ORCID 0000-0003-2942-2357
Colin J B HarveyHexagon Bio, Menlo Park, California 94025, United States.ORCID 0000-0002-4719-7627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ribosome is essential for protein synthesis and targeting its function serves as a platform for many therapies. Resistance gene-guided genome mining for

Indexed as

Ribosomal ProteinsHumansMultigene FamilyRibosomal Proteins

Identifiers

PMID40518819
PMCPMC12203571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.