ArticleACS nano2025
Exploring the Impact of Biotic and Abiotic Surfaces on Protein Binding Modulation and Bacteria Attachment: Integrating Biological and Mathematical Approaches.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Dual-function thermoresponsive antibiotic-loaded hydrogel with antimicrobial and osteogenic properties for implant-related infection control.Bioactive materials · 2026Article
- Investigation of Biofilm Formation and Antimicrobial Resistance in Bacteria Isolated from Hospital Medical Devices.Microorganisms · 2026Article
- An Exploration of Nanobiotechnology Bridging Patho-Therapeutics with Regenerative and Clinical Perspectives in Periodontitis.Journal of functional biomaterials · 2026Review
- Peri-implantitis progression and modulating factors: evidence synthesis and implications for clinical management.Brazilian oral research · 2026Review
- The shifts of submucosal microbiota in treated patients with aggressive periodontitis.Frontiers in oral health · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The oral environment is composed of a diverse array of proteins, and any substrate inserted into this habitat promptly becomes subjected to protein adsorption and bacterial colonization. However, the predictive and modulatory nature of implant surfaces coated with salivary pellicle proteomes in microbial adhesion has not been explored using high-throughput techniques. Thus, using human saliva for salivary pellicle adsorption and microbial accumulation, we compared adsorption and community formation on titanium (Ti) biomaterials (implant devices) and dental surfaces (enamel and dentine). The proteomic profile was evaluated by liquid chromatography coupled with tandem mass spectrometry, and the microbiome was assessed using 16S RNA sequencing. Linear discriminant analysis (LDA) and canonical correlation analysis (CCA) were used to quantify variation in analyte amounts and identify likely biomarkers. Substrates were analyzed regarding their physical, chemical, and topographical properties. Our results showed that the salivary pellicle proteomes on Ti exhibited differences in composition and protein intensities compared with dental surfaces. These differences in proteomes affected the biological processes at the level of microbiome accumulation. Geometric analysis showed greater similarity between Ti and enamel proteomes, while dentine differed markedly. Ti harbors a microbiome community that differs from that of dental surfaces. Canonical correlation analysis (CCA) pinpointed proteins that promoted or inhibited the adherence of specific microbes. Apolipoprotein E showed a strong negative correlation (>0.8) with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.