Evidence map›Paper›PMID 40518609›Full record

ArticleKorean journal of ophthalmology : KJO2025

Managing Pseudophakic Corneal Edema: Structural Changes and Preliminary Observations on Coenzyme Q10 Use.

Umay Güvenç, Züleyha Yalnız Akkaya, Ayşe Burcu

Abstract read
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Article in Korean journal of ophthalmology : KJO, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Umay GüvençDepartment of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkiye.
Züleyha Yalnız AkkayaDepartment of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkiye.
Ayşe BurcuDepartment of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePseudophakic corneal edema (PCE) remains a significant postoperative challenge despite advancements in cataract surgery, often delaying visual recovery and affecting refractive outcomes. This study investigates the relationship between keratometric and pachymetric changes during PCE resolution, evaluates factors influencing this process, and examines the efficacy of coenzyme Q10 (CoQ10) as an adjunct therapy.

methodsA retrospective study was conducted on 88 patients aged 50 years and older who developed PCE after uneventful phacoemulsification. Corneal assessments were performed using Pentacam HR, focusing on keratometric and pachymetric changes. Patients were monitored weekly until PCE resolution, defined as a return of central corneal thickness within ±30 μm of preoperative values. Patients received standard postoperative treatment, with a subset also receiving CoQ10 as an adjunct therapy.

resultsPostoperative visual acuity improved significantly (p < 0.001). Despite pachymetric normalization, persistent keratometric changes were observed, particularly a steepening of posterior curvature (p < 0.001) and increased anterior asphericity (p = 0.047). CoQ10-treated patients exhibited faster edema resolution (p = 0.019), greater reduction in corneal thickness (p = 0.003), and improved transparency. Higher cumulative dissipated energy correlated with increased edema severity (r = 0.419, p < 0.001) and higher cumulative dissipated energy was linked to slower recovery times. Patients with diabetes had a prolonged recovery period compared to nondiabetic patients (p = 0.018), though pachymetric recovery rates were similar. The pachymetric progression index was unreliable in edematous corneas.

conclusionsWhile visual acuity and pachymetry improved in all patients, persistent topographic changes suggest incomplete structural normalization. Preliminary findings indicate that adjunctive CoQ10 use may support more efficient corneal edema resolution, as evidenced by faster recovery and favorable structural changes. Further prospective studies are warranted to confirm these observations.

Indexed as

CorneaCorneal EdemaPhacoemulsificationPostoperative ComplicationsPseudophakiaUbiquinoneAgedAged, 80 and overCorneal PachymetryFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesVisual Acuitycoenzyme Q10UbiquinoneVitaminsCoenzyme Q10Corneal edemaCorneal pachymetryCorneal topographyPhacoemulsification

Identifiers

PMID40518609
PMCPMC12358721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.