Evidence map›Paper›PMID 40518492›Full record

ArticleClinical oral investigations2025

Root canal irrigants and their role in the adhesion of pre-endodontic restorations.

J Francinelli, C Mazzitelli, U Josic, D D'Urso, E Mancuso, G M Moretto, A Mazzoni, S A Salgarello, Lorenzo Breschi, T Maravic

Abstract read
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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J FrancinelliDepartment of Medical and Surgery Specialties, Radiological Sciences and Public Health, Dental School, University of Brescia, Brescia, Italy.
C MazzitelliDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.
U JosicDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.
D D'UrsoDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.
E MancusoDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.
G M MorettoDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.
A MazzoniDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.
S A SalgarelloDepartment of Medical and Surgery Specialties, Radiological Sciences and Public Health, Dental School, University of Brescia, Brescia, Italy.
Lorenzo BreschiDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy. lorenzo.breschi@unibo.it.
T MaravicDepartment of Biomedical and Neuromotor Science, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, Bologna, 40125, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the influence of root canal irrigating protocols on the micro-shear bond strength (µSBS) and endogenous enzymatic activity (MMPs) of pre-endodontic resin composite restorations at baseline and after artificial aging. MATERIALS AND

methodsDeep dentin surfaces from human molars (n = 16) were exposed and embedded in acrylic resin. A universal adhesive (iBond Universal, Kulzer) and resin composite (Venus Pearl, Kulzer) simulated pre-endodontic restorations. The following groups were formed according to the endodontic irrigating protocol (n = 20/group): C (no treatment); SH (5.25% NaOCl + water rinse); CHX (SH + 2% chlorhexidine rinse); EDTA (SH + EDTA rinse). Additional teeth (n = 3) were used for in situ zymography. µSBS and MMPs activity were assessed after 24 h or 10,000 thermocycles (5–55 °C, 30s). Data were statistically analyzed (p < 0.05).

resultsIrrigation, aging, and their interaction significantly influenced µSBS (p < 0.001). At baseline, EDTA showed the highest µSBS (p < 0.05), while C, SH, and CHX were statistically similar (p > 0.05). Thermocycling reduced µSBS in all groups, with no post-aging differences among irrigating protocols (p > 0.05). Enzymatic activity was affected by irrigation and aging. SH showed the highest MMPs activity while CHX the lowest (p < 0.05). No differences were observed between EDTA and C (p > 0.05).

conclusionsIrrigating solutions do not affect the adhesive bond strength of pre-endodontic resin composite restorations after aging. However, enzymatic activity increases after NaOCl, but is reduced when NaOCl is combined with EDTA or CHX. CLINICAL RELEVANCE: Clinically, this supports preserving interproximal pre-endodontic resin composite walls for final restorations.

Indexed as

Dental BondingDental Restoration, PermanentRoot Canal IrrigantsComposite ResinsEdetic AcidHumansIn Vitro TechniquesMaterials TestingShear StrengthComposite ResinsEdetic AcidRoot Canal IrrigantsEndodontically treated teethIrrigating solutionsMetalloproteinasesMMPsPre-endodontic restorationsShear bond strength

Identifiers

PMID40518492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.