Evidence map›Paper›PMID 40518464›Full record

ArticleEJNMMI reports2025

AI based automatic measurement of split renal function in [

Kristian Valind, Johannes Ulén, Anni Gålne, Jonas Jögi, David Minarik, Elin Trägårdh

Abstract read
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Article in EJNMMI reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kristian ValindDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Malmö, Sweden. kristian.valind@med.lu.se.ORCID http://orcid.org/0000-0002-6796-9532
Johannes UlénEigenvision AB, Malmö, Sweden.ORCID http://orcid.org/0000-0003-1625-8367
Anni GålneDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-9050-7889
Jonas JögiDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-5299-3628
David MinarikDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Malmö, Sweden.
Elin TrägårdhDepartment of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-7116-303X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate-specific membrane antigen (PSMA) is an important target for positron emission tomography (PET) with computed tomography (CT) in prostate cancer. In addition to overexpression in prostate cancer cells, PSMA is expressed in healthy cells in the proximal tubules of the kidneys. Consequently, PSMA PET is being explored for renal functional imaging. Left and right renal uptake of PSMA targeted radiopharmaceuticals have shown strong correlations to split renal function (SRF) as determined by other methods. Manual segmentation of kidneys in PET images is, however, time consuming, making this method of measuring SRF impractical. In this study, we designed, trained and validated an artificial intelligence (AI) model for automatic renal segmentation and measurement of SRF in [

resultsKidneys were segmented in 135 [

conclusionsAutomatic measurement of SRF in PSMA PET is feasible. A potential use could be to provide additional data in investigation of renal functional impairment in patients treated for prostate cancer.

Indexed as

AICNNPETPSMARenal functionSegmentationSRF

Identifiers

PMID40518464
PMCPMC12167725

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