Evidence map›Paper›PMID 40518358›Full record

ReviewTrends in immunology2025

Exploring mucosal immune development and function in utero.

Madison S Strine, Brett Vahkal, Kerri St Denis, Liza Konnikova

Abstract readReview
In one paragraph

Review in Trends in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madison S StrineDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06520, USA.
Brett VahkalDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, 06520, USA.
Kerri St DenisDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06520, USA.
Liza KonnikovaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06520, USA; Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06520, USA; Center for Systems and Engineering Immunology, Yale School of Medicine, CT, 06520, USA; Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT 06520, USA; Department of Obstetrics Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: liza.konnikova@yale.edu.

Funding

Function of T cells at the Maternal-Fetal InterfaceR01AI171980 · NIAID · YALE UNIVERSITY · PI Liza Konnikova · 2022 to 2026
$3.5M
Peripheral Immune Development in Premature Infants with and without NECR21HD102565 · NICHD · YALE UNIVERSITY · PI KONNIKOVA, LIZA, TSENG, GEORGE C. · 2020 to 2021
$456k
NIAID NIH HHS R01 AI171980NICHD NIH HHS R21 HD102565
6 · The paper itself

Abstract

Multiomics advances have led to breakthroughs in understanding human early life immunity. Adaptive memory immune cells have been detected in fetal tissue extremely early in gestation, where they may respond to maternal exposures. These promising findings lay the groundwork for future research on the lifelong impact of early immune development.

Indexed as

FetusImmunity, MucosalAnimalsFemaleHumansImmunologic MemoryPregnancy

Identifiers

PMID40518358
PMCPMC12255524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.