ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2025
Aortic Disturbed Flow Is Associated with Aortic Angle in Patients with Tetralogy of Fallot or Double-Outlet Right Ventricle.
Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Four-dimensional flow CMR-based hemodynamic assessment of ALCAPA: A case report.Radiology case reports · 2026Article
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7 authors.
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Abstract
purposeAortopathy, characterized by aortic dilatation caused by cystic medial necrosis, typically develops in adulthood but has been observed at a young age in patients with tetralogy of Fallot. We hypothesized that some patients with tetralogy of Fallot or double-outlet right ventricle experience early-onset aortic disturbed flow. This study aimed to identify and analyze the causes of disturbed flow using 4D flow MRI.
methodsThis study included 24 patients who underwent 4D flow MRI at our institution between January 2022 and September 2024. MRI and cardiac catheterization were performed during follow-up. 4D flow MRI was used to detect disturbed flow and investigate its underlying causes.
resultsThe mean age of patients with tetralogy of Fallot or double-outlet right ventricle was 12 years (range, 1 to 37 years). Of the 24 participants, 11 (46%) exhibited disturbed flow. Patients with disturbed flow had significantly higher Valsalva Z-scores (4.7 ± 3.1 vs. 2.4 ± 1.4, P = 0.013) and a significantly narrower left ventricular outflow tract-ascending aorta angle (113.5 ± 11.6 vs. 127.1 ± 6.7°, P = 0.002). Wall shear stress and energy loss were not significantly different between the 2 groups.
conclusionAortic disturbed flow may occur in patients with tetralogy of Fallot or double-outlet right ventricle, regardless of age, suggesting an association with the left ventricular outflow tract-ascending aorta angle. The occurrence of disturbed flow at a young age should be noted as it may contribute to the future progression of aortopathy.
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