Evidence map›Paper›PMID 40518298›Full record

Observational studyEndocrine journal2025

A 10-year observational study of the effects of serum 25OH vitamin D levels on the onset of prediabetes at a preventive medicine research center.

Kaoru Ogawa, Jun Ogino, Riri Oh, Yukie Sakuma, Koji Takemura, Yoshifumi Suzuki, Yukie Ito, Yuko Endo, Haruhisa Shimura, Kiyoe Kiuchi and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Endocrine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kaoru OgawaDepartment of Diabetes and Metabolic Diseases, Asahi General Hospital, Chiba 289-2511, Japan.
Jun OginoDepartment of Diabetes and Metabolic Diseases, Asahi General Hospital, Chiba 289-2511, Japan.ORCID http://orcid.org/0000-0001-9158-1434
Riri OhDepartment of Diabetes and Metabolic Diseases, Asahi General Hospital, Chiba 289-2511, Japan.
Yukie SakumaClinical Research Support Center, Asahi General Hospital, Chiba 289-2511, Japan.
Koji TakemuraDepartment of Diabetes and Metabolic Diseases, Asahi General Hospital, Chiba 289-2511, Japan.
Yoshifumi SuzukiDepartment of Diabetes and Metabolic Diseases, Asahi General Hospital, Chiba 289-2511, Japan.
Yukie ItoPreventive Medicine Research Center, Asahi General Hospital, Chiba 289-2511, Japan.
Yuko EndoPreventive Medicine Research Center, Asahi General Hospital, Chiba 289-2511, Japan.
Haruhisa ShimuraDepartment of Internal Medicine, Asahi General Hospital, Chiba 289-2511, Japan.
Kiyoe KiuchiDepartment of Clinical Laboratory, Asahi General Hospital, Chiba 289-2511, Japan.
Saburo WatanabeClinical Research Support Center, Asahi General Hospital, Chiba 289-2511, Japan.
Yasunori SatoDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan.
Shouji YoshidaDepartment of Internal Medicine, Asahi General Hospital, Chiba 289-2511, Japan.
Naotake HashimotoPreventive Medicine Research Center, Asahi General Hospital, Chiba 289-2511, Japan.ORCID http://orcid.org/0009-0000-3790-6226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the findings of a 10-year study that followed the relationship between serum 25-hydroxyvitamin D (25OH vitamin D) levels and the onset of prediabetes, analyzed based on sex. One hundred eighty-seven participants were followed who had a baseline hemoglobin A1c (HbA1c) value below 6.0% and fasting plasma glucose level below 100 mg/dL. The cut-off values for vitamin D concentration were 27.7 ng/mL for men and 17.1 ng/mL for women, based on the receiver operating characteristic curve. The prediabetes incidence was significantly higher in women with a vitamin D concentration ≤17.1 ng/mL [HR = 7.08 (2.08-24.2), p = 0.002] than in men with a concentration ≤27.7 ng/mL [HR = 2.30 (0.63-8.35), p = 0.21], based on the cumulative incidence function curve. Multivariate analysis revealed that an abdominal circumference ≥90 cm and 25OH vitamin D concentration ≤17.1 ng/mL were independent, significant and intervenable risk factors for prediabetes in women. Low levels of vitamin D in women can be a predictive factor in the development of diabetes after 10 years.

Indexed as

Prediabetic StateVitamin DVitamin D DeficiencyAdultAgedBlood GlucoseFemaleGlycated HemoglobinHumansIncidenceMaleMiddle AgedPreventive MedicineRisk FactorsSex FactorsWaist Circumference25-hydroxyvitamin DBlood GlucoseGlycated HemoglobinVitamin DAbdominal circumferencePrediabetesVitamin D

Identifiers

PMID40518298
PMCPMC12436077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.