ArticleThe Journal of veterinary medical science2025
A pilot study investigating renal biomarkers in dogs with pulmonary hypertension: a comparison between cystatin-C, symmetric dimethylarginine, and creatinine.
Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary hypertension (PH) can affect renal function, yet renal dysfunction in canine PH is relatively underexplored. Cystatin C (CYS-C), a useful marker for evaluating renal function in humans with PH, has not been studied in dogs. This study aimed to compare seventeen dogs with PH to a control group, evaluating the relationship between PH and renal parameters such as symmetric dimethylarginine (SDMA), creatinine, and CYS-C. The mean tricuspid regurgitation maximal velocity (TRmax) and systolic pulmonary arterial pressure (SPAP) in dogs with PH was 4.24 m/sec and 74.48 mmHg, respectively. Dogs with PH exhibited significantly higher SDMA (15.47 μg/dL vs. 10.55 μg/dL) and CYS-C (1.36 mg/L vs. 0.88 mg/L) compared to controls. SDMA showed moderate positive correlations with SPAP (r=0.682) and TRmax (r=0.662), and a negative moderate correlation with mean arterial pressure (r=-0.590). CYS-C moderately correlated with SPAP (r=0.529), TRmax (r=0.485), heart rate (r=0.506), and body weight (r=0.691). Creatinine did not vary significantly between PH group (122.21 μmol/L) and controls (93.70 μmol/L), nor did it correlate with any parameters. Multivariate analysis revealed that CYS-C was significantly influenced by PH severity, while SDMA and creatinine were not. These findings suggest that renal dysfunction is prevalent in dogs with PH. CYS-C may be a more sensitive marker for detecting early renal changes linked to PH severity, while SDMA appears to be more specific to true renal dysfunction and creatinine was the least informative biomarker.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.